KABUL, Afghanistan (AP) - A massive explosion rocked a highly secure diplomatic area of Kabul on Wednesday morning, killing 80 people and wounding as many as 350, an attack that left a scene of mayhem and destruction and sent a huge plume of smoke over the Afghan capital.
The target of the attack -- which officials said was a suicide car bombing -- was not immediately known, but Ismail Kawasi, spokesman of the public health ministry, said most of the casualties were civilians, including women and children.
It was one of the worst attacks Kabul has seen since the drawdown of foreign forces at the end of 2014.
Associated Press images from the scene showed the German Embassy and several other embassies located in the area heavily damaged in the explosion. It wasn't known if any foreign diplomats were among the casualties but Germany and Pakistan said some of their embassy employees and staff were hurt in the explosion.
The explosion took place at the peak of Kabul's rush hour when roads are packed with worktime commuters. It went off close to a busy intersection in the Wazir Akbar Khan district, said Najib Danish, deputy spokesman for the Interior Ministry.
The neighborhood is considered Kabul's safest area, with foreign embassies protected by dozens of 10-foot-high blast walls and government offices, guarded by police and national security forces. The German Embassy, the Foreign Ministry and the Presidential Palace are all in the area, as are the British and the Canadian embassies. The Chinese, Turkish and Iranian embassies are also located there.
Local TV footage showed shocked residents soaked in blood stumbling about, then being ferried away to hospitals. Passers-by stopped and helped the wounded into their private cars, others congregated outside the nearby Italian-run Emergency Hospital.
No group immediately claimed responsibility for the blast. Both the Taliban and the Islamic State group have staged large-scale attacks in the Afghan capital in the past.
The Afghan Taliban later issued a statement denying any involvement in the bombing and condemning all attacks against civilians. Zabihullah Mujahid, spokesman for the Taliban, said Wednesday's explosion had "nothing to do with the Mujahedeen of Islamic Emirate," as the Taliban call themselves.
But even though the Taliban claim they are only waging war against the Kabul government and foreign forces in Afghanistan, most of the casualties of their attacks have been civilians.
A statement from the Ministry of Interior Affairs said it "condemns in the strongest terms the terrorist attack" that killed so many, including women and children. "These heinous acts go against the values of humanity as well values of peaceful Afghans," it added.
Afghan President Ashraf Ghani also condemned the attack, which came just days into the Muslim holy month of Ramadan. A statement from his office quoted Ghani as saying that "the terrorists, even in the holy month of Ramadan, the month of goodness, blessing and prayer, are not stopping the killing of our innocent people."
Germany's Foreign Minister Sigmar Gabriel said an unspecified number of German Embassy employees in Kabul were hurt in the blast and an Afghan security guard outside the building was killed. Gabriel said all embassy workers were safe and offered his condolences to the family of the slain guard.
Pakistan also denounced the "terrorist attack in Kabul" and its Ministry of Foreign Affairs said it "caused damage to the residences of some Pakistani diplomats and staff, living in the close vicinity, and inflicted minor injuries to some."
China's foreign ministry said its Kabul embassy in Kabul was partly damaged but that all embassy staff were "safe and sound" and that there had been no reports of injured Chinese citizens.
Germany has had troops in Afghanistan for 15 years, primarily concentrated in the north in and around Mazar-E-Sharif. They're currently one of the biggest contributors to the NATO-led Resolute Support mission with around 980 soldiers on the ground to support and train Afghan security forces.
Wednesday's explosion was so heavy that more than 50 vehicles were either destroyed or damaged at the site of the attack. "We don't know at this moment what was the target of the attack," said Danish.
Residents described a mushroom cloud over Kabul and windows were shattered in shops, restaurants and other buildings up to a kilometer (half mile) from the blast site.
"There are a large number of casualties, but I don't know how many people are killed or wounded," said an eyewitness, Gul Rahim.
Kawasi, the health official, said the wounded were admitted to different Kabul hospitals.
Shortly after the explosion, all roads in Wazir Akbar Khan were blocked off by Afghan security forces and helicopters were deployed over the neighborhood.
Last month, the Afghan Taliban announced the beginning of their spring offensive, promising to build their political base in the country while focusing military assaults on the international coalition and Afghan security forces.
U.S. and Afghan forces have been battling the Taliban insurgency for more than 15 years. The United States now has more than 8,000 troops in Afghanistan, training local forces and conducting counterterrorism operations. In the past year, they have largely concentrated on thwarting a surge of attacks by the Taliban, who have captured key districts, such as Helmand province, which U.S. and British troops had fought bitterly to return to the government.
Associated Press writer David Rising in Berlin contributed to this report.