I-495 southbound was closed south of the Philadelphia Pike in Claymont, Del. after a multi-vehicle crash occurred Friday morning.
Police say three cars were involved in the wreck around 10:15 a.m.
It is not known at this time if there were any injuries.
Traffic was being diverted on to I-95 as investigators collected information and clean-up crews worked to clear the wreckage.
The road was reopened after a two hour closure.