PHILADELPHIA (AP) -- Cam Newton tossed a 1-yard touchdown pass to Greg Olsen with 1:22 left and the Carolina Panthers overcame a 17-point deficit in the fourth quarter to beat the Philadelphia Eagles 21-17 on Sunday.
Wes Horton sacked Carson Wentz, forcing a fumble on fourth down from the Panthers 14 to seal the victory.
The Panthers improved to 4-2 with the biggest comeback in franchise history. The defending Super Bowl champion Eagles fell to 3-4.
After Carolina took the lead, the Eagles started at their 30. A 48-yard pass interference penalty on James Bradberry against Alshon Jeffery put the ball at the Carolina 22. Eric Reid appeared to intercept Wentz's overthrown pass but the play was overturned on a video review. Wentz threw incomplete to Jeffery in the end zone on third-and-2 and was stripped on the next play.
Down 17-0, the Panthers started their rally when Curtis Samuel ran in from the 14 on a reverse but Graham Gano missed the extra point.
Newton then quickly drove the Panthers 87 yards, tossing an 18-yard pass to Devin Funchess. He connected with Jarius Wright on the 2-point conversion to get Carolina within a field goal with 4:08 left.
The Panthers forced a three-and-out and got the ball at their 31 with 2:17 remaining.
Newton threw three straight incomplete passes, but took a hit on fourth down and still completed a 35-yard catch-and-run pass to Torrey Smith to reach the Philadelphia 34. A 22-yard pass to Christian McCaffrey gave Carolina first down at the 4. Newton ran it to the 1, setting up third down. He threw it to Olsen wide open in the back of the end zone.
Newton finished 25 of 39 for 269 yards and ran for 49 yards.
Wentz's 11-yard TD pass to Jeffery gave Philadelphia a 7-0 lead in the second quarter. Ertz had catches of 15 and 22 yards on the drive and Jeffery hauled in a 20-yard pass before the score.
Jeffery and his teammates had a unique celebration. He placed the ball on the ground and pretended to do a free kick.
Wentz tossed a 1-yard TD to Dallas Goedert to make it 17-0 in the third quarter, finishing off a 17-play, 94-yard drive that chewed up 9:22 on the clock.
Gano made a 39-yard field goal that was nullified by a false start. He missed from 44 yards, but another false start allowed the Panthers to try again and they punted.
NOT GETTING ALONG
Reid and Eagles safety Malcolm Jenkins exchanged words and were separated before the coin toss. The two men have history going back to last year when Reid left The Players Coalition, which was co-founded by Jenkins. Reid and Jenkins are both fighting for the same cause -- social and racial injustice -- but have disagreed over how to do it. Reid recently called the coalition "an NFL funded subversion group" and he strongly supports his friend, Colin Kaepernick.
Reid also got into it with Ertz after tackling Wentz following a handoff in the first quarter. Both guys received personal foul penalties.
Reid again took a knee during the national anthem. He's been doing it since Kaepernick, his former teammate on the 49ers, began taking a stance in 2016.
Panthers: DE Mario Addison twice left the game with a back injury and didn't return after going out in the fourth quarter.
Eagles: RB Darren Sproles (hamstring), CB Sidney Jones (hamstring), DT Haloti Ngata (calf) and S Corey Graham (hamstring) were among the key players out of the lineup.
Panthers: Host the Baltimore Ravens on Sunday.
Eagles: Play the Jacksonville Jaguars in London on Sunday.