Cardinals try to secure playoff berth against 49ers

LEFT: Kyler Murray #1 of the Arizona Cardinals throws the ball against the Philadelphia Eagles at State Farm Stadium on December 20, 2020 in Glendale, Arizona. (Photo by Norm Hall/Getty Images) RIGHT: Quarterback Jimmy Garoppolo #10 of the San Franci

The Arizona Cardinals have their destiny in their own hands. The road they would have to take, however, could be awfully bumpy to get there.

If the Cardinals win the next two games or a combination of one win and a Chicago Bears loss, they will return to the playoffs for the first time since 2015. However, those two games are against divisional opponents that figure to make the job awfully difficult, starting on Saturday when Arizona will host the injury-depleted San Francisco 49ers (4:30, Prime Video) at State Farm Stadium.

FOX Bet Sportsbook is your sports betting home to get the latest odds, prop bets and bet boosts. Check it out now for special promotions when you open an account. FOX Bet is available in Pennsylvania, New Jersey, Colorado and Michigan through the FOX Bet app and online at

The sports betting information

On Sportsbook, the Cardinals are five point favorites with a money line of minus-225. (A $225 bet is needed to win $100.) The Cardinals are at +187 on the money line – a $100 bet will yield a $1875 win. The over/under total is 48 ½ points.

Arizona is 7-7 against the spread this year with San Francisco at 5-9, the second worst mark in the league ahead of only Dallas’ 4-10 mark.

There are plenty of CustomBets, PropBets and other wagers available at to suit any gambling needs.  Check it out now.

The history

Arizona won the last meeting between the two on Opening Day as Kyler Murray threw for one touchdown, rushed for 91 yards and another score in the Cardinals 24-20 win. Kenyan Drake’s one yard run with 5:03 to play proved to be the game winner for Arizona.

The 49ers lead the series 31-27 overall. Arizona, however, has won 10 of the last 13 games between the two dating back to the 2014 season.

The storylines to watch

After a three-game losing streak that pushed the Cardinals to the brink of playoff extinction, Arizona has bounced back with two very solid wins against the Giants (26-7) and Eagles (33-26.) Murray had his best day as a passer, throwing for 406 yards and three touchdowns while posting a 127.8 quarterback rating. DeAndre Hopkins was stellar, catching nine passes for 169 yards and the game-winning 20 yard touchdown pass from Murray with 7:17 to go. Arizona can be streaky, but they need to ride this momentum if they want to get into the tournament.

On the flip side, the 49ers are a battered mess right now. At 5-9, San Francisco will become the second straight Super Bowl participant from the NFC West not to make the playoff the following season. A large portion of that is the injury situation at quarterback, which has seen Jimmy Garoppolo miss most of the season with multiple injuries and now Nick Mullens is out with a right elbow injury that could require Tommy John surgery. The 49ers added well-traveled quarterback Josh Rosen to the roster to backup third stringer C.J. Beathard, who will get the start on Saturday. Raheem Mostert is expected to miss the final two games of the San Francisco season due to a high ankle sprain.

FOX Bet operates a mobile and online sportsbook and a free-to-play game.
For FOX Bet Sportsbook: Must be 21+. NJ, PA and CO only. Complete terms and conditions can be found in the app and at FOX Bet Services are operated by TSG Interactive US Service LTD. Gambling Problem? Call 1-800-Gambler (NJ, PA) or 1-800-522-4700 (CO).